Program

Program for The joint ICMS-AACR International Conference on Tumor Microenvironment March 6-10, 2007

Tuesday, March 6, 2007 (Palazzo Vecchio)

Opening Session

19:00 Greetings:

Isaac P. Witz, Tel Aviv, Israel, President, International Cancer Microenvironment Society

Margaret Foti, Philadelphia, USA, Chief Executive Officer, American Association for Cancer Research

Raffaella Giavazzi, Bergamo, Italy, President, Italian Cancer Society

19:30 Opening lecture

Alberto Mantovani, Milan, Italy MOLECULAR LINKS BETWEEN INFLAMMATION AND CANCER

20:15 Welcome Reception

Wednesday, March 7, 2007

Plenary Session I - Gene Expression Regulation in the Tumor Microenvironment -Auditorium

Session dedicated to the memory of Raphael Kafka

Chairperson: Eitan Yefenof

08:30 Menashe Bar-Eli, Houston, TX, USA TRANSCRIPTIONAL REGULATION IN MELANOMA PROGRESSION: IMPLICATIONS FOR THERAPY

08:55 Hans Clevers, Utrecht, The Netherlands Wnt AND Notch COOPERATE TO MAINTAIN PROLIFERATIVE COMPARTMENTS IN CRYPTS AND INTESTINAL NEOPLASIA

09:20 Avraham Raz, Detroit, MI, USA DOWN-REGULATION OF PHOSPHOGLUCOSE ISOMERASE/AUTOCRINE MOTILITY FACTOR RESULTS IN MESENCHYMAL-TO-EPITHELIAL TRANSITION OF HUMAN LUNG FIBROSARCOMA CELLS

09:45 Yoel Kloog, Tel Aviv, Israel THE PALMITATES AND THE HYPERVARIABLE REGION OF H-Ras: RASOSOMES, H-Ras/GALECTIN-1 COMPLEX FORMATION, TRAFFICKING AND SIGNALING

10:10 Margareta M. Müller, Heidelberg, Germany

MOLECULAR NETWORKS THAT ACTIVATE THE TUMOR MICROENVIRONMENT AND PROMOTE TUMOR PROGRESSION

10:35 Valerie M. Weaver, Philadelphia, PA, USA SPATIAL-MECHANICAL REGULATION OF MALIGNANT TRANSFORMATION AND TREATMENT RESPONSE

11:00-11:30 – Coffee

Plenary Session II - Inflammatory Reactions in the Tumor Microenvironment -

Auditorium

Session dedicated to the memory of Jacqueline Seroussi

Chairperson: Margaret Foti

11:30 Frances Balkwill, London, UK MODIFYING THE INFLAMMATORY CYTOKINE NETWORK OF HUMAN CANCER

11:55 Giorgio Trinchieri, Frederick, MD, USA TOLL-LIKE RECEPTOR SIGNALING IN HEMATOPOIETIC AND NON-HEMATOPOIETIC CELLS: ROLE IN CANCER

12:20 Jeffrey W. Pollard, Bronx, NY, USA TUMOR-EDUCATED MACROPHAGES PROMOTE TUMOR PROGRESSION AND ENHANCE METASTASIS

12:45 Lisa M. Coussens, San Francisco, CA, USA INFLAMMATION, HUMORAL IMMUNITY AND CANCER DEVELOPMENT

13:10-14:30 – Lunch

Plenary Session III - Immune Functions in the Tumor Microenvironment -

Auditorium

Session dedicated to the memory of Diana Mary and Dr. Stanley Steyer

Chairperson: Raffaella Giavazzi

14:30 Ron N. Apte, Beer Sheba, Israel THE IMPORTANCE OF MOLECULES OF THE IL-1 FAMILY IN CARCINOGENESIS AND TUMOR INVASIVENESS

14:55 Theresa L. Whiteside, Pittsburgh, PA, USA TUMOR-DERIVED MICROVESICLES AND THEIR BIOLOGIC EFFECTS: ANOTHER WAY FOR TUMORS TO ESCAPE FROM THE IMMUNE SYSTEM

15:20 Wolf H. Fridman, Paris, France LOCAL IMMUNE CONTEXTURE, METASTASIS AND SURVIVAL IN COLORECTAL CANCER

15:45 Richard Bankert, Buffalo, NY, USA IN SITU TARGETING OF QUIESCENT HUMAN TUMOR­ASSOCIATED MEMORY T CELLS IN THE TUMOR MICROENVIRONMENT FOR RE-ACTIVATION AND TUMOR KILLING: A THERAPEUTIC STRATEGY

16:10 Sharon Evans, Buffalo, NY, USA LOCAL MICROENVIRONMENTAL CONTROL OF CD8 T CELL TRAFFICKING WITHIN THE TUMOR MICROENVIRONMENT

16:35-17:00 -Coffee

Plenary Session IV - Tumor-Associated Stroma and Extracellular Matrix -

Auditorium

Chairperson: Angelo Messina

17:00 Lynn Matrisian, Nashville, TN, USA

THE MATRIX METALLOPROTEINASES AS MEDIATORS OF TUMOR: HOST COMMUNICATION

17:25 Harold L. Moses, Nashville, TN, USA STROMAL AND EPITHELIAL TGF-ß SIGNALING IN CANCER

17:50 Israel Vlodavsky, Haifa, Israel THE IMPACT OF HEPARANASE ON TUMOR METASTASIS AND ANGIOGENESIS

20:30 – Conference Dinner

Thursday, March 8, 2007

Symposium I – Local Tumor Immunity -Auditorium

Chairperson: Eva Klein

08:30 Luca Vannucci, Prague, Czech Republic A PARADOXICAL HYPOTHESIS: MIGHT A CONTROLLED IMMUNE SUPPRESSION HELP TO RESCUE THE IMMUNE RESPONSE IN A PRO-INFLAMMATORY TUMOR MICRO-ENVIRONMENT?

08:42 Karin Jöhrer, Innsbruck, Austria MYELOMA-DERIVED CHEMOKINES AND THEIR IMPACT ON IMMUNE CELL HOMEOSTASIS AND RESPONSE

08:54 Janet E. Price, Houston, TX, USA CXCL12 AS A MEDIATOR OF INTERACTIONS BETWEEN BREAST CANCER CELLS AND THE BONE MICROENVIRONMENT

09:06 Beatriz Arteta, Bizkaia, Spain TUMOR-ACTIVATED ENDOTHELIAL MANNOSE RECEPTOR CONTRIBUTES TO REGIONAL IMMUNE TOLERANCE DURING EXPERIMENTAL COLON CARCINOMA METASTASIS TO THE LIVER

09:18 Milada Sirova, Prague, Czech Republic IMMUNOSTIMULATORY EFFECT OF HPMA-BASED POLYMERIC CONJUGATE IN TUMOUR TREATMENT

09:30 Stephanie Darmanin, Sapporo, Japan ALL-TRANS RETINOIC ACID ENHANCES MURINE DENDRITIC CELL MIGTATION TO DRAINING LYMPH NODES VIA THE BALANCE OF MATRIX METALLOPROTEINASES AND THEIR INHIBITORS

Symposium II – Angiogenesis and Transendothelial Migration -Auditorium

Chairperson: Menashe Bar-Eli

09:45 Elena Voronov, Beer-Sheva, Israel TUMOR-DERIVED INTERLEUKIN-1 BETA IS A MAJOR FACTOR IN TUMOR ANGIOGENESIS

09:57 Jin Chen, Nashville, TN, USA A CRITICAL ROLE OF EphA2 RECEPTOR TYROSINE KINASE IN TUMOR ANGIOGENESIS

10:09 Ido Nevo, Tel-Aviv, Israel THE INVOLVEMENT OF FRACTALKINE IN BONE-MARROW­ENDOTHELIUM TRANSMIGRATION OF NEUROBLASTOMA CELLS

10:21 Irene F. Newsham, Houston, TX, USA DISSECTING THE EXTRAVASATION PROCESS OF METASTATIC BREAST CANCER CELLS USING AN ELECTRIC CELL SUBSTRATE IMPEDANCE SYSTEM (ECIS) ASSAY

10:33 Ashleigh Hill, Belfast, Northern Ireland, UK CD44 REGULATES THE EXPRESSION OF THE PROTEASES CATHEPSIN K AND MT1-MMP IN BREAST CANCER CELLS: IMPLICATIONS FOR METASTASIS TO BONE

10:45 Suzanne McFarlane, Belfast, Northern Ireland, UK CORTACTIN AND PAXILLIN ARE KEY INTERMEDIATES IN CD44­INITIATED INTEGRIN MEDIATED ADHESION OF BREAST CANCER CELLS TO BONE MARROW ENDOTHELIUM

10:57 Michael E. Maragoudakis, Patras, Greece NEW INSIGHTS INTO THE ROLE OF THROMBIN IN ANGIOGENESIS AND TUMOR PROGRESSION

11:10-11:30 – Coffee

Symposium III – Targeting Tumor – Microenvironment Interactions –

Sala Verde

Chairperson: Wolf H. Fridman

08:30 Youcef M. Rustum, Buffalo, NY, USA MODULATION OF TUMOR MICROENVIRONMENT BY SELENIUM CORRELATES WITH ENHANCED THERAPEUTIC EFFICACY

08:50 Mark Pines, Bet Dagan, Israel INHIBITION OF FIBROBLAST TO MYOFIBROBLAST TRANSITION BY HALOFUGINONE CONTRIBUTE TO THE CHEMOTHERAPY­MEDIATED ANTI-TUMORAL EFFECT

09:02 Eva Corey, Seattle, WA, USA TREATMENT OF OSTEOBLASTIC METASTASES OF PROSTATE CANCER WITH ANTI-RESORPTIVE AGENTS DECREASES TUMOR GROWTH

09:14 Irit Gil-Ad, Petah-Tiqva, Israel EVIDENCE FOR THE ANTI-TUMOR ACTIVITY OF THE ANTIDEPRESSANT SERTRALINE AGAINST SENSITIVE AND MULTI DRUG RESISTANT CANCER CELLS AND IN A MICE COLON CARCINOMA MODEL

09:26 Gary Acton, London, UK REVIEW OF PHASE II STUDIES OF THE VASCULAR DISRUPTING AGENT DMXAA (AS1404) IN COMBINATION WITH CHEMOTHERAPY

09:38 Clarisa Salado, Bizkaia, Spain ANTIMETASTATIC INTERVENTION SITES FOR RESVERATROL IN THE INFLAMMATORY MICROENVIRONMENT GENERATED BY TUMOR-ACTIVATED HEPATIC SINUSOIDAL ENDOTHELIAL CELLS

09:50 Kellie A. Charles, London, UK CLINICAL INVESTIGATION OF THE BIOLOGICAL ACTIVITY OF AN ANTI-TNF- ALPHA MONOCLONAL ANTIBODY, INFLIXIMAB, IN THE TUMOUR MICROENVIRONMENT OF PATIENTS WITH ADVANCED OVARIAN CANCER

10:02 Laura F. Gibson, Morgantown, WV, USA MICROENVIRONMENT SUPPORT OF A UNIQUE LEUKEMIC CELL POPULATION WITH STEM CELL PROPERTIES

10:14 Sumanta Goswami, New York, NY, USA TUMOR MICROENVIRONMENT INDUCED INVASIVE AND DRUG RESISTANT BREAST CANCER CELLS

10:26 Fabio Pastorino, Genoa, Italy TARGETING LIPOSOMAL CHEMOTHERAPY VIA BOTH TUMOR CELL-SPECIFIC AND TUMOR VASCULATURE-SPECIFIC LIGANDS POTENTIATES THERAPEUTIC EFFICACY

10:38 Bratko Filipič, Ljubljana, Slovenia EXTRACELLULAR Ca++ IONS AFFECT THE CYTOCIDAL AND ANTIPROLIFERATIVE ACTIVITY OF HUMAN INTERFERON α

10:50-11:30 – Coffee

Symposium IV – Local Expressions of Inflammation – Sala Verde

Session dedicated to the memory of Professor Shraga Segal

Chairperson: Ron Apte

11:30 Eli Pikarsky, Jerusalem, Israel NF-κB IN HEPATOCARCINOGENESIS - LESSONS FROM DIFFERENT ANIMAL MODELS

11:50 Adi Zipin-Roitman, Tel-Aviv, Israel CXCL10 PROMOTES INVASIVE-RELATED PROPERTIES IN COLORECTAL CARCINOMA CELLS

12:02 Venkateshwar G. Keshamouni, Ann Arbor, MI, USA TGF-BETA-INDUCED IRAK-M EXPRESSION IN TUMOR ASSOCIATED MACROPHAGES REGULATES LUNG TUMOR PROGRESSION

12:14 Nicholas J. Clemons, Cambridge, UK THE LUMINAL MICROENVIRONMENT IN THE DEVELOPMENT OF OESOPHAGEAL ADENOCARCINOMA

12:26 Sandra O. Gollnick, Buffalo, NY, USA NEUTROPHILS PLAY A CRITICAL ROLE IN DEVELOPMENT OF TUMOR SPECIFIC CD8+ T CELL RESPONSES

12:38 Christoph Peters, Freiburg, Germany INVASION AND METASTASIS OF MAMMARY CANCER DEPENDS ON TUMOR- AND STROMA-CELL DERIVED CYSTEINE CATHEPSINS

12:50 Gwendal Lazennec, Montpellier, France INTERLEUKIN-8 (IL-8) IS AN IMPORTANT MARKER FOR BREAST CANCER METASTASIS

13:02 Janine T. Erler, Stanford, CA, USA TUMOR-SECRETED LYSYL OXIDASE IS REQUIRED FOR METASTATIC NICHE

13:14 Ioannis Stasinopoulos, Baltimore, MD, USA LOSS OF COX-2 LIMITS TUMOR GROWTH AND INHIBITS METASTASIS

Symposium V – Signaling and Regulation of Gene Expression I – Auditorium

Chairperson: Avraham Raz

11:30 Antonella Naldini, Siena, Italy HYPOXIA INDUCES THE EXPRESSION OF PROTEASE-ACTIVATED RECEPTOR (PAR)-1 THROUGH THE HYPOXIC INDUCIBLE FACTOR (HIF)-1Α IN BREAST CANCER CELLS

11:50 Marcelo Ehrlich, Tel-Aviv, Israel PHOSPHOLIPASE D IS AN EFFECTOR AND REGULATOR OF THE EPITHELIAL TO MESENCHYMAL TRANSITION OF MOUSE MAMMARY TUMOR CELLS

12:10 Robert Gatenby, Tucson, AZ, USA THE ROLES OF MICROENVIRONMENTAL HYPOXIA AND ACIDOSIS IN CARCINOGENESIS

12:22 Hongyan Cui, Sapporo, Japan ENHANCED EXPRESSION OF ASPARAGINE SYNTHETASE UNDER GLUCOSE-DEPRIVED CONDITIONS PROTECTS PANCREATIC CANCER CELLS FROM APOPTOSIS INDUCED BY GLUCOSE DEPRIVATION AND CISPLATIN

12:34 Elena Tirrò, Catania, Italy SILENCING OF BCR-ABL/JAK2-INDUCED SURVIVIN SENSITIZES IMATINIB RESISTANT CML CELLS TO HYDROXYUREA

12:46 Maria Grazia Borrello, Milan, Italy ONCOGENE-INDUCED PROMOTION OF AN INFLAMMATORY MICROENVIRONMENT: THE THYROID MODEL

12:58 Carlton D. Donald, Charleston, SC, USA THE PAX2 ONCOGENE MAY PROMOTE CANCER CELL SURVIVAL THROUGH THE SUPPRESSION OF IMMUNE-MEDIATED RECOGNITION AND DESTRUCTION: NEW INSIGHT TO A NOVEL TARGET FOR CANCER THERAPY

13:10 Medhat Shehata, Vienna, Austria LYMPHOID MICROENVIRONMENT SUPPORTS SURVIVAL OF B­CLL CELLS: ROLE OF TGF-BETA AND PI3-K/Akt PATHWAY

13:22 Andrei Thomas-Tikhonenko, Philadelphia, PA, USA c-Myc-REGULATED MicroRNAs PROMOTE TUMOR GROWTH THROUGH EFFECTS ON ANGIOGENESIS AND TUMOR MICROENVIRONMENT

Afternoon free

Friday, March 9, 2007

08:30-10:00 – Poster Session – Auditorium

10:00-10:30 – Coffee

Symposium VI - Signaling and Regulation of Gene Expression II - Auditorium

Chairperson: Adriana Albini

10:30 Rachel Bar-Shavit, Jerusalem, Israel PAR1 IN MALIGNANT AND PHYSIOLOGICAL INVASION: IDENTIFICATION OF LINKERS TO BETA-CATENIN, PROMOTER SIGNATURES & SILENCING MODALITIES

10:50 Zaidoun Salah, Jerusalem, Israel TRANSCRIPTIONAL REGULATIONS OF hPAR1 IN PROSTATE CARCINOMA

11:02 Andrei V. Bakin, Buffalo, NY, USA NEW INSIGHTS IN THE MECHANISMS OF THE TGF-BETA EFFECTS ON TUMOR MICROENVIRONMENT AND THE METASTATIC POTENTIAL

11:14 Ugo Cavallaro, Milan, Italy THE NCAM/FGFR COMPLEX: A NOVEL CROSS-TALK INVOLVED IN METASTASIS?

11:26 Cameron N. Johnstone, Philadelphia, PA, USA PARVIN-BETA, A NEGATIVE REGULATOR OF INTEGRIN-LINKED KINASE SIGNALING, MODULATES CELLULAR INVASION AND PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA ACTIVITY

11:38 Manikuntala Kundu, Kolkata, India HELICOBACTER PYLORI-MEDIATED SIGNALING IN GASTRIC EPITHELIAL CELLS AND ITS IMPLICATIONS IN HELICOBACTER­MEDIATED GASTRIC ULCER AND GASTRIC CARCINOMA

11:50 Tiziana Triulzi, Milan, Italy RELEVANCE OF BREAST CARCINOMA EXTRACELLULAR MATRIX COMPOSITION IN DRUG SENSITIVITY

12:02 Rosaria Orlandi, Milan, Italy EXREACELLULAR MATRIX (ECM) - DRIVEN ANALYSIS OF GENE EXPRESSION DATA FROM BREAST AND OVARIAN CANCER

Symposium VII – Tumor- Stroma Interactions – Sala Verde

Chairperson: Israel Vlodavsky

10:30 Maty Tzukerman, Haifa, Israel THE HUMAN EMBRYONIC STEM CELL-DERIVED MICROENVIRONMENT HAS THE POTENTIAL TO UNVEIL CANCER SUBPOPULATIONS THAT DO NOT DEVELOP INTO TUMORS IN CONVENTIONAL MURINE XENOGRAFTS

10:50 Edna Cukierman, Philadelphia, PA, USA ALTERED 3D-ADHESIONS SUPPORT A Src/FAK DEPENDENT INTEGRIN CROSSTALK DURING STROMAGENESIS

11:10 Luuk J.A.C. Hawinkels, Leiden, The Netherlands

MATRIX METALLOPROTEINASE-9 (MMP-9) MEDIATES TUMOUR CELL VEGF RELEASE INDUCING ENDOTHELIAL CELL ANGIOGENESIS

11:22 Zoi Diamantopoulou, Patras, Greece P10, A PEPTIDE WITH ANTI TUMOUR BIOLOGICAL ACTIONS

11:34 Iker Badiola, Leioa, Spain IMPLICATION OF DISCOIDIN DOMAIN RECEPTORS IN THE ACTIVATION OF HEPATIC STELLATE CELLS DURING LIVER METASTASIS

11:46 Amitava Chatterjee, Kolkata, India CULTURE OF HUMAN BREAST CANCER CELLS (MCF-7) IN PRESENCE OF FIBRONECTIN IN SERUM FREE MEDIUM ACTIVATES MMP-2 & MMP-9

11:58 Susan Deutscher, Columbia, MO, USA NOVEL IN VIVO TUMOR-IMAGING AND TARGETING AGENTS USING GALECTIN-3 PEPTIDE AGONISTS

12:10 Delia Mezzanzanica, Milan, Italy DELOCALIZATION OF ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE FROM THE CELL MEMBRANE IS A MOLECULAR PREDICTOR OF SURVIVAL IN ADVANCED OVARIAN CARCINOMA PATIENTS

12:30-14:00 – Business Meeting and Lunch -Auditorium

Plenary Session V - Tumor-Endothelium Interactions - Auditorium

Chairperson: Kari Alitalo

14:00 Eli Keshet, Jerusalem, Israel VEGF-INDUCED RECRUITMENT OF PRO-ANGIOGENIC CIRCULATING CELL

14:25 Jaques Huot, Québec, QC, Canada BI-DIRECTIONAL SIGNALLING INDUCED BY E-SELECTIN AND DEATH RECEPTOR-3 IN COLON CANCER METASTASIS

Plenary session VI – Dangerous Liaisons in the Tumor Microenvironment -

Auditorium

Chairperson: Eiichi Tahara

14:50 Yves DeClerck, Los Angeles, CA, USA CONTRIBUTION OF BONE MARROW MESENCHYMAL CELLS TO BONE METASTASIS

15:15 Kelvin P. Lee, Buffalo, NY, USA DENDRITIC CELLS SUPPORT MULTIPLE MYELOMA CELL SURVIVAL THROUGH CD28 RECEPTOR ACTIVATION

15:40 Neta Erez, San Francisco, CA, USA ROLES OF CARCINOMA ASSOCIATED FIBROBLASTS IN MOUSE MODELS OF CERVICAL AND SKIN CARCINOGENESIS

16:05-16:30 – Coffee

Plenary session VII – Targeting the Tumor Microenvironment: Preclinical and Clinical Trials I -Auditorium

Session dedicated to the memory of Mary A. Pikovski

Chairperson: Yves DeClerck

16:30 Alexander Levitzki, Jerusalem, Israel ERADICATING EGFR OVER-EXPRESSING TUMORS BY TARGETED DELIVERY OF PolyIC

16:55 Eiichi Tahara, Hiroshima, Japan A MODEL FOR COMPREHENSIVE PREVENTION OF GASTRIC CANCER BASED ON NOVEL BIOMARKERS AND LONGITUDINAL HEALTH DATABASE OF ATOMIC BOMB SURVIVORS

17:20 Adriana Albini, Milan, Italy THE MICROENVIRONMENT AS A TARGET OF CANCER CHEMOPREVENTION

17:45 Yona Keisari, Tel Aviv, Israel IN SITU DESTRUCTION OF SOLID MALIGNANT CANCER BY COMBINATION RADIO-PHYSICO-CHEMICAL TREATMENTS AND ACTIVATION OF ANTI-TUMOR IMMUNITY

18:10 Benjamin Bonavida, Los Angeles, CA, USA YING YANG 1 (YY1) AND RAF KINASE INHIBITOR PROTEING (RKIP) REGULATE TUMOR CELL RESISTANCE TO APOPTOSIS BY CHEMO-IMMUNOTHERAPY

20:30 -Farewell Evening

Saturday, March 10, 2007

Plenary session VIII – Targeting the Tumor Microenvironment: Preclinical and Clinical Trials II -Auditorium

Chairperson: Fernando Vidal-Vanaclocha

08:30 Michael R. Shurin, Pittsburgh, PA, USA DENDRITIC CELLS IN THE TUMOR MICROENVIRONMENT: FROM EXPERIMENTS TO THERAPY

08:55 Fernando Vidal-Vanaclocha, Bilbao, Viscaya, Spain MICROENVIRONMENT-DEPENDENT GENE EXPRESSION PATTERNS IN HEPATIC METASTASES FROM COLON CARCINOMA PATIENTS. PHARMACOGENOMIC IMPLICATIONS

09:20 Daniel Zagury, Paris, France THE UTILITY OF TNFα VACCINATION IN THE PREVENTION OF CACHEXIA AT TERMINAL STAGES OF CANCER

09:45 Ruth Lupu, Evanston, IL, USA BLOCKADE OF A KEY MOLECULAR-ACTIVATION SWITCH IN THE SUB-DOMAIN III OF ER2 EXTRACELLULAR DOMAIN (ECD) RECAPITULATES THE ANTI-HER2 ACTIONS OF TRASTUZUMAB, PERTUZUMAB AND LAPATINIB

10:10 Bonnie Hylander, Buffalo, NY, USA DEFINING THE ANTI-TUMOR EFFICACY OF Apo2L/TRAIL AGAINST PATIENT-DERIVED PANCREATIC TUMOR XENOGRAFTS IN SCID MICE

10:35 Adriana Haimovitz-Friedman, New York, NY, USA bFGF AND VEGF INHIBIT RADIATION-INDUCED APOPTOSIS OF ENDOTHELIAL CELLS BY INHIBITING ACID SPHINGOMYELINASE ACTIVITY

11:00-11:30 – Coffee

Plenary session IX – The Tumor Microenvironment Drives Tumor Progression- Auditorium

Chairperson: Suresh Mohla

11:30 Eva Klein, Stockholm, Sweden CONTRIBUTION OF EBV INFECTION AND THE MICROENVIRONMENT TO THE DEVELOPMENT OF HODGKIN’S AND NK-LYMPHOMAS

11:55 Catherine Sautès-Fridman, Paris, France TRAF4 OVEREXPRESSION IS A COMMON CHARACTERISTIC OF HUMAN CARCINOMA

12:20 Yves St-Pierre, Laval, QC, Canada GALECTIN-7 PLAYS A CENTRAL ROLE IN TUMORIGENESIS

12:45 Judith Leibovici, Tel Aviv, Israel THE AGED ORGANISM AS A MALIGNANCY REDUCING MICROENVIRONMENT

13:10 Jan Zeromski, Poznan, Poland EXPRESSION OF TOLL-LIKE RECEPTORS IN THE MICROENVIRONMENT OF LARYNGEAL CARCINOMA

13:35 -Adjourn