Sunday, June 10, 2018 | |
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| 15:00-18:00 | Registration |
| 18:00-19:30 |
Opening sessionChair: Eitan Yefenof, Israel Greetings: Prof. Carmo Fonseca, President of the Lisbon Medical Academic Center and IMM Opening lecture:Isaac Witz, Israel: The Tumor and its Environment: A Love-Hate relationship |
| 19:30-21:00 | Get together |
Monday, June 11, 2018 | |
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| 08:30-10:30 |
Plenary session 1: Regulatory pathways at the Tumor MicroenvironmentAuditorium I Chair: Michal Banyiash, Israel |
| 8:30 |
John Condeelis, USA: High resolution intravital imaging of tumor cell dissemination and seeding of distant sites in invasive carcinoma |
| 9:00 | Avraham Raz, USA: Galectin-3: A marker for understanding/improving bone tumor microenvironment management |
| 9:30 | Jonathan Sleeman, Germany: A new role for VEGF-C in metastatic conditioning of the lung |
| 10:00 | Luyuan Li, China: Oxygen-Independent Degradation of Hypoxia- Inducible Factor 1-Alpha |
| 10:30-11:00 | coffee break, Poster viewing |
| 11:00-13:00 |
Plenary session 2: Targeting the Tumor MicroenvironmentAuditorium I Chair: Galina Shurin, USA |
| 11:00 | Alberto Mantovani, Italy: The Yin-Yang Of Innate Immunity, Inflammation And Cancer |
| 11:30 | Yuval Shaked, Israel: Host mediated effects in response to anti-cancer drugs and their clinical implications |
| 12:00 | John Delinasios, Greece: Proliferating fibroblasts against cancer cells in vitro |
| 12:30 | Maty Tzukerman, Israel: Shaping the soil for the seeds: Reciprocal reprogramming of cancer cells and associated Mesenchymal Stem Cells in gastric cancer |
| 13:00- 14:00 | Lunch |
| 14:00 |
Special Guest PresentationAuditorium I Chair: Isaac Witz, Israel Anna Dart, London, Associate Editor, Nature Reviews Cancer: Publishing in nature research journals |
| 14:30-16:30 |
Plenary session 3: Inflammation and the tumor microenvironmentAuditorium I Chair Catherine Sautes-Fridman, France |
| 14:30 | Michal Banyiash, Israel: Plasticity and biological diversity of myeloid derived suppressor cells: Clinical implications. |
| 15:00 | Adit Ben Baruch, Israel: Inflammation-driven networks in the regulation of breast cancer progression |
| 15:30 | Yves De Clerck, USA: Mesenchymal Stromal Cells: Mediators of Inflammation in Cancer |
| 16:00 | Ron Apte, Israel: Microenvironment IL-1beta as a major balance between tumor-promoting inflammation and anti-tumor immunity |
| 16:30-17:00 | Coffee break, Poster viewing |
| 17:00-19:00 |
Plenary session 4: The Tumor Neuro-microenvironmentAuditorium I Chair: Maria Rita Dionísio, Portugal |
| 17:00 | Bozena Kaminska, Poland: Identification and therapeutic targeting interactions between glioma and its microenvironment (Sponsored by the EACR) |
| 17:30 | Michael Shurin, USA: The role of tumor-neural-immune axis at the tumor microenvironment |
| 18:00 | Christopher Gerner, Austria: From cutaneous metastasis to brain metastasis: proteome signatures and functional features of melanoma cells |
| 18:30 | Marcel Alexander Heinrich, The Netherlands: 3D Bioprinted mini-brains: a novel tool to study the interaction between Tumor-associated macrophages and cancer cells in glioblastoma multiforme |
| 20:00 | Conference dinner |
Tuesday, June 12, 2018 | |
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| 08:30-10:30 |
Parallel sessions I |
| Session 5A |
Regulatory pathways at the Tumor MicroenvironmentAuditorium I Chair: Zvi Granot, Israel |
| 08:30 |
Rachel Bar-Shavit, Israel: Cancer driver G-protein coupled receptors; GPCRs: Molecular mechanism and translational means |
| 08:45 | Sandrina Nóbrega Pereira, Portugal: The Role of mitochondrial metabolism in breast cancer aggressiveness induced by hypercholesterolemia |
| 09:00 | Sofia C Nunes, Portugal: Enzymes involved in cysteine metabolism underlie hypoxia adaptation in ovarian cancer |
| 09:15 | Sofia Avnet, Italy: Acidosis and 3D interactions between tumor cells and mesenchymal stroma are crucial for profound cellular rewiring toward the regulation of lipid metabolism |
| 09:30 | Jesús Francisco Glaus Garzón, Switzerland: Gut microbiota-induced alterations of mucus glysosylation modulated cancer progression |
| 09:45 | Ana Felix, Portugal: Integrin and Laminin332 Different Expression in the Two Main Histological Types of Cervical Carcinomas |
| 10:00 | Filipa Lopes-Coelho, Portugal: HNF1β, an oncogene-like protein, is stabilized by acetylation, preventing its ubiquitination and further degradation |
| 10:15 | Dalit Barkan, Israel: Soluble Mediators of Resolution-Promoting Macrophages Inhibit Breast Cancer Recurrence at the Metastatic Niche |
| Session 5B |
The Metastatic Tumor MicroenvironmentAuditorium lI Chair: Bruno Costa-Silva, Portugal |
| 08:30 | Paulina Podszywalow-Bartnicka, Poland: Stress-induced signaling in chronic myeloid leukemia promotes cells invasiveness |
| 08:45 | Joana Carvalho, Portugal: Extracellular Vesicles: (fine) tuning the gastric cancer microenvironment |
| 09:00 | Zhe Liu Liu, China: Lymphocyte mimicry in epithelial cancer metastasis |
| 09:15 | Lee Shaashua, Israel: Micro-metastases regression following primary tumor excision: a critical role for primary tumor secretome |
| 09:30 | Tali Tavor Re'em, Israel: Constructing a dynamic three Dimensional in vitro model for investigation of ovarian carcinoma progression mechanisms |
| 09:45 | Reuven Reich, Israel: Role of S1P Signaling in ovarian carcinoma progression |
| 10:00 | Michael Grusch, Austria: Fibroblast growth factor-Induced EMT in malignant pleural mesothelioma aggressiveness |
| 10:15 | Zhi-Xiong Jim Xiao, China: Regulation of AMPK in cancer cell metabolism and tumor metastasis |
| Session 5C |
Inflammation and Immunity at the Tumor MicroenvironmentAuditorium III Chair: Yaacov Ben-David, China |
| 08:30 | Imad Shams, Israel: New insights into cancer- and hypoxia-resistance in the blind mole rat, Spalax |
| 08:45 | Francesca Caccuri, Italy: U94 of human herpesvirus 6 down-modulates Src, promotes a partial mesenchymal-to-epithelial transition and inhibits tumor cell growth, invasion and metastasis |
| 09:00 | Lukas Hawinkels, The Netherlands: Endoglin expression on cancer-associated fibroblasts regulates invasion and stimulates colorectal cancer metastasis |
| 09:15 | Andrei Bakin, USA: A novel cellular crosstalk promoting tumor progression and metastasis |
| 09:30 | Chiara Polidoro, Italy: Lox-1 affects tumor growth and colon cancer neoangiogenesis acting by VEGF-A165 |
| 09:45 | Nikolitsa Nomikou, UK: Exploiting the tumour microenvironment in order to optimise sonodynamic therapy for prostate cancer |
| 10:00 | Ana Paula Delgado, USA: Single cell RNA-Seq analysis of breast cancer progression |
| 10:15 | Catarina Brito, Portugal: 3D-3-culture: a tool to unveil tumour-macrophage crosstalk in the tumour microenvironment |
| 10:30-11:00 | Coffee break, Poster viewing |
| 11:00-13:00 |
Parallel sessions II |
| Session 6A |
Regulatory pathways at the Tumor MicroenvironmentAuditorium I Chair: Maria Jose Oliveira, Portugal |
| 11:00 | Jan A Burger, USA: The role of nurselike cells In the CLL microenvironment |
| 11:15 | Fares Qeadan, USA: P-value and its relationship to the effect size when modeling cytokines using the measure of stochastic superiority |
| 11:30 | Alba Herrero, Spain: Role of ICAM-1 and COX-2 in angiogenic and desmoplasic response by HSC recruitment |
| 11:45 | Allan Lipton, USA:Extracellular matrix (ECM) protein fragments in serum and outcomes in metastatic breast and pancreatic cancer patients |
| 12:00 | Michal Masarik, Czech Republic: Cell stiffness as a predictor of metastatic potential and therapy response in head and neck tumours |
| 12:15 | Sarah Ouahoud, The Netherlands: TRAIL produced by SMAD4 deficient tumors stimulates BMP2 production by fibroblasts and enhances colorectal cancer (CRC) invasiveness |
| 12:30 | Stefanie Kirchberger, Austria: Illuminating the tumor microenvironment in zebrafish cancer models |
| 12:45 | Marta Laranjeiro Pinto, Portugal: Profiling macrophage populations in human colorectal cancer |
| Session 6B |
Inflammation and Immunity at the Tumor MicroenvironmentAuditorium II Chair: Adriana Haimovitz-Friedman, USA |
| 11:00 | Barbara Bottazzi, Italy: Migration Stimulating Factor, a new marker for M2-polarization affecting monocyte motility |
| 11:15 | Nuno Lopes, Portugal: Exploiting 3D Co-culture Models to Depict the Phenotype of Tumor Associated Macrophages in Breast Cancer |
| 11:30 | Maria José Oliveira, Portugal: Profiling macrophage populations in human colorectal cancer |
| 11:45 | Adi Karsch-Bluman, Israel: Effect of Necrosis on Cancer Resistance Mechanisms |
| 12:00 | Shimrit Avraham, Israel: Host ATF3 and JDP2 expression in the tumor microenvironment plays a dual role in carcinogenesis |
| 12:15 | Marta D. Kolba, Poland: Tunneling Nanotubes (TNTs) mediate bidirectional transfer of specific vesicular cargo and proteins between leukemia and stroma cells |
| 12:30 | Bin Shan, USA: Epigenetic activation of a novel isoform of lncRNA HOTAIR in lung and breast cancer cells attached to extracellular matrix |
| 12:45 | Raj Tiwari, USA: Tumor microenvironment of anaplastic thyroid cancer: Novel inflammatory and immunotherapeutic targets |
| Session 6C |
Targeting the Tumor MicroenvironmentAuditorium III Chair: Tali Feferman, Israel |
| 11:00 | Reichle Albrecht, Germany: Anakoinosis: Reprogramming communicative networks in tumor systems, a review |
| 11:15 | Praneeth Reddy Kuninty, The Netherlands: Targeting integrin alpha 5 attenuates pancreatic tumor progression by abolishing tumor stroma |
| 11:30 | Kévin Louault, France: Interactions between cancer associated fibroblasts and tumor cells promotes MCL-1 dependency in luminal breast cancers |
| 11:45 | Silvia Laura Locatelli, Italy: Targeting the Hodgkin lymphoma tumor microenvironment through PI3K gδ inhibition |
| 12:00 | Deby Fajar Mardhian, The Netherlands: Relaxin-coated iron-oxide nanoparticles as a novel approach to inhibit tumor stroma in pancreatic tumor |
| 12:15 | Lina Ghibelli, Italy: Mechanisms of post-therapy tumor cell repopulations |
| 12:30 | Rajkumar Savai, Germany: Circulating fibrocytes plays a key role in lung tumor progression by modulating macrophage phenotype, angiogenesis and endothelin system |
| 12:45 | Zofia Pilch, Poland: Manipulation of CD200R signaling potentiates the anti-cancer effect of TLR7 agonist |
| 13:00 | Free afternoon |
Wednesday, June 13, 2018 | |
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| 08:30-10:30 |
Parallel sessions III |
| Session 7A |
Regulatory pathways in the Tumor MicroenvironmentAuditorium I Chair: Karine Serre, Portugal |
| 08:30 | Elena Bruni, Italy: NKp46 marks a novel Vd1-restricted gδT subset with potent anti-tumor activity resident in human intestinal mucosa |
| 08:45 | Sarah Baird, New Zealand: Cathepsin D enhances mesenchymal stem cell homing to tumour sites, where through production of tissue inhibitor of matrix metalloproteinases, they can reduce metastasis |
| 09:00 | Ruowen Ge, Singapore: Nucleolin is a novel cell-surface receptor for ADAMTS5 that mediates the antiangiogenic function of ADAMTS5 |
| 09:15 | Ubaldo Soto, USA: Stem cell secreted factors induce changes in alpha-6 integrin splicing in skin melanoma and breast cancer cells leading to a less oncogenic phenotype |
| 09:30 | Sérgia Velho, Portugal: KRAS mediates colorectal cancer cell invasion induced by fibroblasts |
| 09:45 | Mahmoud Dabbah, Israel: CD49d expression on bone marrow mesenchymal stem cells’ microvesicles as a therapeutic target in multiple myeloma |
| 10:00 | Rinat Abramovitch, Israel: Elucidating the effects of chronic liver inflammation on colorectal cancer metastatic dissemination |
| 10:15 | Ada Rephaeli, Israel: Histone deacetylase inhibitory prodrugs of low molecular weight fatty acids AN7 and AN446 modify the tumor microenvironment |
| Session 7B |
Inflammation and Immunity at the Tumor MicroenvironmentAuditorium II Chair: John Delinasios, Greece |
| 08:30 | Angela M Costa, Portugal: The hypoxia impact in the macrophage-driven cancer cell invasive phenotype |
| 08:45 | Marta Laranjeiro Pinto, Portugal: Unraveling the immunomodulatory role of colorectal cancer extracellular matrix on macrophage polarization |
| 09:00 | Michael Goldberg, USA: T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity |
| 09:15 | Tali Feferman, Israel: Oxygen deprivation during T cell priming boosts tumor rejection in a mouse melanoma model |
| 09:30 | Charlotta Dabrosin, Sweden: Dense breast tissue and breast cancer in women exhibit similar pro-inflammatory microenvironment in vivo |
| 09:45 | Zvi Granot, Israel: The TRPM2 Ca2+ channel links EMT and tumor cell susceptibility and neutrophil cytotoxicity |
| 10:00 | Svetlana Miklikova, Slovakia: Breast cancer related changes of adipose tissue-derived mesenchymal stromal cells |
| 10:15 | Valeria Quaranta, UK: Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer |
| Session 7C |
Targeting the Tumor MicroenvironmentAuditorium III Chair: Sandra Casimiro, Portugal |
| 08:30 | Milada Sirova, Czech Republic: Targeted modulation of tumor microenvironment using polymer drug delivery systems |
| 08:45 | Karine Serre, Portugal: Different TLR signalling pathways induce macrophages or neutrophils with anti-tumour functions in vivo |
| 09:00 | Fourniols Thibaut, Belgium: Targeting tumor associated fibroblasts with an antibody-grafted lipid nanocapsule |
| 09:15 | Marie-Ève Wedge, Belgium: Tailoring oncolytic viruses for the treatment of pancreatic cancer |
| 09:30 | Flávia Castro, Portugal: Reprogramming antigen-presenting cells: a chitosan/g-PGA nanoparticles for anticancer therapy |
| 09:45 | Avraham Dayan, Israel: RGD-modified Dihydrolypoamide Dehydrogenase Conjugated to TiO2 Nanoparticles – Application in Integrin-Targeted Photodynamic Treatment of Melanoma Cells |
| 10:00 | Mark Schoonderwoerd, The Netherlands: Synergistic inhibition of tumor growth by combined endoglin and anti-programmed cell death-1 (PD1) targeting in colorectal cancer |
| 10:15 | Adriana Haimovitz-Friedman, USA: Activation of anti-tumor immune response by partial-volume SINGLE dose radiation |
| 10:30-11:00 | Coffee break, Poster viewing |
| 11:00-13:00 |
Parallel sessions IV |
| Session 8A |
Inflammation and Immunity at the Tumor MicroenvironmentAuditorium I Chair: Reichle Albrecht, Germany |
| 11:00 | Wu-Min Deng, USA: The transitional region in epithelial tissues is hotspot for tumorigenesis |
| 11:15 | Ruth Scherz-Shouval, Israel:Stromal stress networks underlying phenotypic plasticity and tumor fitness |
| 11:30 | Yaacov Ben-David, China: Erythropoietin elicits a strong immune response against leukemic cells leading to tumor inhibition |
| 11:45 | Lazennec Gwendal, France: Involvement of chemokines in breast cancer aggressiveness |
| 12:00 | Dominika Piasecka, Polland:Inflammatory stimuli promote growth of HER-2 negative non-invasive mammary epithelial cells |
| 12:15 | Carles Urbiola, Austria: Tumor Cytokine Profile in Oncolytic Virotherapy of Solid Tumors with VSV-GP |
| 12:30 | Lubor Borsig, Switzerland:Chemokine-induced vascular permeability promotes lung metastasis |
| 12:45 | Valentin Baloche, France:Contribution of galectin-9 to tumor immune escape: basic and pre-clinical investigations in the CT26 murine tumor model |
| Session 8B |
Cellular and Molecular interactions at the Tumor MicroenvironmentAuditorium II Chair: Sergio Dias, Portugal |
| 11:00 | Bettina Couderc, France:Mesenchymal stromal cells are involved in chemoresistance and macrophages polarization through the CXCR1/2 ligands’s release |
| 11:15 | Sofia Mensurado, Portugal:Tumor-associated neutrophils suppress pro-tumoral IL-17+ gδT cells through induction of oxidative stress |
| 11:30 | Victoria Jennings, UK:Enhancing oncolytic virotherapy by exosome-mediated microRNA reprograming of the tumour microenvironment |
| 11:45 | Marcello Ehrlich,Israel: Manipulation of the Tumor Microenvironment through a Three-Way Molecular Tug-of-War: Oncogenic Signaling, Innate Immune Anti-Viral Responses and Viral Oncolysis |
| 12:00 | Ismael Sánchez-González, Germany:miR-149 functions as a tumor suppressor by controlling invasive motility through both cell intrinsic and paracrine signaling mechanisms |
| 12:15 | Azzarone Bruno, France: Interleukin 15 is a major player in renal cancer progression |
| 12:30 | Reuven Stein, Israel: Targeting CD38 in the tumor microenvironment inhibits progression of primary melanoma and generation of spontaneous metastasis |
| 12:45 | Raya Leibowitz-Amit, Israel: Immune checkpoint and micro-RNA networks at the tumor side of the immunological synapse in cancer – implications for immunotherapy |
| Session 8C |
Preclinical and Clinical TrialsAuditorium III Chair: Jose Carlos Machado, Portugal |
| 11:00 | Anette Hauge, Norway: Exploring the Tumor Microenvironment with Functional Magnetic Resonance Imaging |
| 11:15 | Soraia Lobo de Martins, Portugal: Neutrophil to lymphocyte ratio (NLR) as a predictor of overall survival in patients with metastatic castration resistant prostate cancer (mCRPC) treated with Radium-223 |
| 11:30 |
Tommaso Cavalleri, Italy: Combined low densities of FoxP3+ and CD3+ tumor-infiltrating lymphocytes for the intra-stage II identification of colorectal cancers with the highest risk of progression |
| 11:45 | Filipa G. Marques, Portugal:Neovascularization is induced in human peritumoral tissues after radiotherapy |
| 12:00 | Sandra Casimiro, Portugal: Prognostic role of secreted YB-1 in patients with breast cancer |
| 12:15 | Lutz Menzel, Germany: Remodeling of the lymph node vascular environment in aggressive B cell lymphoma involves distinct morphologies and signaling pathways |
| 13:00-14:00 | Lunch |
| 14:00-14:30 |
Business MeetingAuditorium I |
| 14:30-16:30 |
Plenary session 9: The Metastatic MicroenvironmentAuditorium I Chair: Bozena Kaminska, Poland |
| 14:30 | Achim Krueger, Germany: Nomen non est omen: Pro-metastatic signaling functions of tissue inhibitor of metalloproteinases-1 (TIMP-1) |
| 15:00 | Arne Ostman, Sweden: , Prognostic and response-predictive potential marker-defined tumor-stroma cell subsets |
| 15:30 | Menashe Bar-Eli, USA: A-to-I micro RNA editing and melanoma metástases |
| 16:00 | Heike Allgayer,, Germany: The genomic landscape characterizing metastasis |
| 16:30-17:00 | Coffee break, Poster viewing |
| 17:00-19:00 |
Plenary session 10: The immune-microenvironment of CancerAuditorium I Chair: Bernd Groner, Switzerland |
| 17:00 | Wolf Fridman, France: Cancer and micro-environmental factors that tune T cell responses |
| 17:30 | Shimon Sakaguchi, Japan: Targeting regulatory The cells in tumor microenvironment |
| 18:00 | Shlomo Elias, Israel: Immune evasion by oncogenic fusion proteins of acute myeloid leukemia |
| 18:30 | Chatherine Sautes- Fridman, France: Tertiary lymphoid structures in cancer: friends or foes? |
Thursday, June 14, 2018 | |
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| 08:30-10:30 |
Plenary session 11: Clinical aspects of Tumor Microenvironment ResearchAuditorium I Chair: Heike Allgayer, Germany |
| 8:30 | Luis Costa, Portugal: Targeting the microenvironment of solid tumors: Clinical achievements and challenges |
| 9:00 | Yona Keisari, Israel: Elimination of human and mouse solid malignant tumors by intra-tumoral Ra-224 loaded sources in combination with systemic chemotherapy and immunotherapy |
| 9:30 | Emiliano Calvo, Spain: Why are there no advances in the therapy of pancreatic cancer? |
| 10:00 | Jai Prakash, The Netherlands: A novel integrin alpha5 binding peptide for tumor stroma imaging and potentiating the effects of chemotherapy in pancreatic cancer |
| 10:30-11:00 | Coffee break |
| 11:00 |
Closing sessionAuditorium I Poster Session – Presentation of Best Posters and Awarding of Prizes - Sponsored by the EACREitan Yefenof, Israel: Summary and Outlook |
| 12:00 | Adjourn |